Pair Name	Thymoquinone, Cyclophosphamide
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in Sub-G1 phase
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Expression	CCND1	hsa595
	Up-regulation	Expression	PTEN	hsa5728
In Vitro Model	SK-BR-3	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0033
	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
Result	The current findings suggested that TQ can alter the cell cycle progression and induce cell death independent of FASN mediated signaling. In terms of clinical perspective, the present study clearly showed that TQ can broadly augment the effect of cyclo in breast cancer cases irrespective of Her-2+ or Her-.